Keywords

• Best price 70288-86-7
• Ivermectin Fast Delivery
• Ivermectin powder 70288-86-7

Quick Details

• ProName: Best price 70288-86-7 Ivermectin Fast ...
• CasNo: 70288-86-7
• Molecular Formula: C48H74O14
• Appearance: white powder
• Application: Health care grade,API,
• DeliveryTime: 5-7 working days
• PackAge: Bottle, Drum, Vacuum Packed, Plastic b...
• Port: China major port
• ProductionCapacity: 55 Metric Ton/Month
• Purity: 99%
• Storage: Sealed, dry and refrigerated
• Transportation: By Express,Air,Sea
• LimitNum: 1 Kilogram
• Related Substances: Ivermectin
• Residue on Ignition: <5
• Heavy Metal: <10ppm
• Valid Period: 2 Years
• Active Ingredient: Ivermectin
• Specification: 99%
• Einecs No.: 274-536-0
• Application: Health care grade，API
• Sample: 5-10g
• MOQ: 1KG
• Place of Origin: Shaanxi， China
• Brand Name: QUANAO

Superiority

Best price 70288-86-7 Ivermectin Fast Delivery  Ivermectin powder 

Ivermectin is white or light yellow crystalline powder and soluble in methyl alcohol, ester and aromatic hydrocarbon but water. Ivermectin is a kind of antibiotic medicine which has a driving and killing effect on nematodes, insects and mites. Injection and troche which are made from ivermectin are mainly used in the treatments of livestock’s gastrointestinal nematode, bovine hypodermosis, calf fly maggot, sheep nasal fly maggot, and scabies of sheep and pigs. Besides, ivermectin can also be available for the treatment of plant-parasitic nematodes(ascarid, lungworm) in poultry. In addition, it can also be made into agricultural insecticide to kill mite, plutella xylostella, cabbage caterpillar, leaf miner, phylloxera and nematode which are widely parasitic in plants. The most outstanding feature of this insecticide is that it has little side effects and can drive and kill many kinds of parasites both internally and externally at a time.

Ivermectin (MK-933, IVM) is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug. Ivermectin (MK-933, IVM) is a specific positive allosteric effector of P2X4 and α7 nicotinic acetylcholine receptors (nAChRs). Ivermectin has potent antiviral activity towards both HIV-1 and dengue virus. Ivermectin induces autophagy through the AKT/mTOR signaling pathway and mitophagy.

Ivermectin binds selectively and with high affinity to glutamate-gated chloride ion channels in invertebrate muscle and nerve cells of the microfilaria. This binding causes an increase in the permeability of the cell membrane to chloride ions and results in hyperpolarization of the cell, leading to paralysis and death of the parasite. Ivermectin also is believed to act as an agonist of the neurotransmitter gamma-aminobutyric acid (GABA), thereby disrupting GABA-mediated central nervous system (CNS) neurosynaptic transmission. Ivermectin may also impair normal intrauterine development of O. volvulus microfilariae and may inhibit their release from the uteri of gravid female worms.
 

Details

Ivermectin is a medication that is effective against many types of parasites. It is used to treat head lice, scabies, river blindness, strongyloidiasis, and lymphatic filariasis, among others. Ivermectin and other avermectins (insecticides most frequently used in home-use ant baits) are macrocyclic lactones derived from the bacterium Streptomyces avermitilis. Ivermectin kills by interfering with nervous system and muscle function, in particular by enhancing inhibitory neurotransmission. Ivermectin is a mixture of mostly avermectin H2B1a (CAS# 71827-03-7) with some avermectin H2B1b (CAS# 70209-81-3), which are macrolides from STREPTOMYCES avermitilis.

• Product name

  Ivermectin, Positive allosteric modulator of alpha7 nicotinic acetylcholine receptors

• Description

  Positive allosteric modulator of α7 nicotinic acetylcholine receptors

• Biological description

  Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptor. Allosteric effector of P2X₄ receptors. Antihelmintic. Modulates glutamate- and GABA-activated chloride channels. Potentiates glycine-gated currents at low concentrations (30 nM).

• Purity

  > 96%

• CAS Number

  70288-86-7

• Chemical structure