Keywords

• in bulk supply 458-37-7
• Curcumin China
• 95% Curcumin 458-37-7

Quick Details

• ProName: in bulk supply 458-37-7 Curcumin China...
• CasNo: 458-37-7
• Molecular Formula: C21H20O6
• Appearance: Ornage powder
• Application: colorant，Food grade.
• DeliveryTime: 5-7 working days
• PackAge: Bottle, Drum, Vacuum Packed, Plastic b...
• Port: China major port
• ProductionCapacity: 55 Metric Ton/Month
• Purity: 99%
• Storage: Sealed, dry and refrigerated
• Transportation: By Express,Air,Sea
• LimitNum: 1 Kilogram
• Residue on Ignition: <1.0
• Heavy Metal Content: 10ppm
• Valid Period: 2 years
• Product Name: Turmeric root extract
• Specification: Raw Materials Powder，curcumin
• Appearance: Orange powder
• EINECS: 207-280-5
• Sample: 5-10g
• MOQ: 1KG
• Test Method: HPLC
• Brand Name: QUANAO

Superiority

in bulk supply 458-37-7 Curcumin China 95% Curcumin  458-37-7

Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, and antitumor activities. It inhibits nitric oxide (NO) production (IC₅₀ = 6 μM) and reduces inducible nitric oxide synthase (iNOS) activity in LPS-stimulated RAW 264.7 cells.Curcumin inhibits release of histamine and the inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8 from HMC-1 mast cells. In vivo, curcumin decreases serum levels of histamine and TNF-α, inhibits histopathological changes of nasal mucosa, and decreases the number of sneezes and nasal rubbing in a mouse model of ovalbumin-induced rhinitis. Curcumin (100 or 200 mg/kg) prevents ovalbumin-induced accumulation of 3-nitrotyrosine (3-NT), a marker of oxidative stress, in mouse heart. Topical administration of curcumin (1-10 μmol) reduces the number of tumors induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mouse skin. Dietary administration of curcumin reduces the number of tongue neoplasms and preneoplastic lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in rats.

Curcumin is a yellow-orange dye obtained from tumeric, the powdered root of Curcuma longa. Curcumin is employed in the preparation of curcuma paper, the detection of boron, and possesses a vast number of biological targets. Curcumin has been shown to inhibit NF-κB, possibly through inhibition of JNK (IC50=10 μM). Curcumin blocks amyloid peptide induced expression of: TNF-α, IL-1β, MCP-1, IL-8, and CCR5, regulates NOS2, inhibits IgE and Ag-induced degranulation of mast cells, inhibits 5-LO (5-lipoxygenase) (IC50=8 μM), Cox-2 (cyclooxygenase-2) (IC50=52 μM), the COP9 signalosome kinase (IC50=10 µM), and p300/CBP. This wide range of activities makes Curcumin an extremely useful tool for developing novel analogues and uses.

Details

• Product name

  Curcumin (high purity), Lipoxygenase and COX inhibitor

• Description

  High purity. Lipoxygenase and COX inhibitor

• Biological description

  High purity flavonoid derivative. Potent antioxidant, anti-inflammatory, analgesic and anticancer agent. Lipooxygenase and cyclooxygenase inhibitor (IC₅₀ values are 8 and 52 μM, respectively). Shows diverse range of actions including free radical scavenging activity, cardio and neuroprotective effects. Blood brain barrier permeable. Active in vitro and in vivo

• Purity

  > 98%

• CAS Number

  458-37-7

• Chemical structure