Xi'an Quanao Biotech Co., Ltd.
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CAS NO.38183-03-8
98%(50-250)Gram98%(251-500)Gram
Building Healthy Life
Professional Factory
We has a complete production and operating system, with an annual output capacity of 2000 tons. It can produce variety of content and proportion of extract according to the demand.
High Quality Best price supply 98% 7,8-Dihydroxyflavone / 7,8-DHF Powder
| Product Name: 7,8-Dihydroxyflavone Powder |
| Raw material: Compound |
| Appearance: Yellow Fine Powder |
| Specification: 98% |
| Test Method: HPLC |
| CAS No. / M.F. / M.W. : 38183-03-8/ C15H10O4 / 254.34 |
Biotin, also known as vitamin H or coenzyme R, is a water-soluble B-vitamin (vitamin B7).
It is composed of a ureido (tetrahydroimidizalone) ring fused with a tetrahydrothiophene ring. A valeric acid substituent is attached to one of the carbon atoms of the tetrahydrothiophene ring. Biotin is a coenzyme for carboxylase enzymes, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis.
7,8-Dihydroxyflavone (7,8-DHF) is a naturally occurring flavone found in Godmania aesculifolia, Tridax procumbens, and primula tree leaves. It has been found to act as a potent and selective small-molecule agonist of the tropomyosin receptor kinase B (TrkB) (Kd ≈ 320 nM), the main signaling receptor of the neurotrophin brain-derived neurotrophic factor (BDNF).
7,8-DHF is both orally bioavailable and able to penetrate the blood–brain barrier. A prodrug of 7,8-DHF with greatly improved potency and pharmacokinetics, R7, is under development for the treatment of Alzheimer's disease.
7,8-DHF has demonstrated remarkable therapeutic efficacy in animal models of a variety of central nervous system disorders,
including depression, Alzheimer's disease, cognitive deficits in schizophrenia, Parkinson's disease, Huntington's disease,
amyotrophic lateral sclerosis, traumatic brain injury, cerebral ischemia, fragile X syndrome, and Rett syndrome.
7,8-DHF also shows efficacy in animal models of age-associated cognitive impairment and enhances memory consolidation and emotional learning in healthy rodents.
In addition, 7,8-DHF possesses powerful antioxidant activity independent of its actions on the TrkB receptor, and protects against glutamate-induced excitotoxicity, 6-hydroxydopamine-induced dopaminergic neurotoxicity, and oxidative stress-induced genotoxicity.
