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CAS NO.36062-04-1
95%(100-1000)Gram95%(1000-5000)Gram
Buy 36062-04-1 High Purity Tetrahydrocurcumin 36062-04-1 Tetrahydrocurcumin powder
Tetrahydrocurcumin is a metabolite of curcumin (Item Nos. 81025 | 81025.1) that has diverse biological activities, including antioxidant, anti-inflammatory, anti-angiogenic, and anticancer properties. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay with an EC50 value of 16.8 μM. Tetrahydrocurcumin (50 µM) inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS) and COX-2 expression in RAW 264.7 cells. It also inhibits LPS-induced increases in TNF-α release when used at a concentration of 100 µM and increases in nitric oxide (NO) production and IL-6 levels in a concentration-dependent manner. Tetrahydrocurcumin reduces carrageenan-induced paw edema in rats (ED50 = 20 mg/kg). It also reduces the formation of neocapillaries and decreases microvascular density as well as VEGF, VEGF receptor 2 (VEGFR2), and hypoxia-inducible factor-1α (HIF-1α) expression in a CaSki cervical cancer nude mouse xenograft model when administered at doses of 100, 300, and 500 mg/kg.
Tetrahydro Curcumin is a major metabolite of Curcumin (C838500) that has been shown to have protective effects against diabetes and vascular dysfunction via alleviation of oxidative stress.
Catalogue Number | T293385 |
Chemical Name | Tetrahydro Curcumin |
Synonyms | 1,7-Bis(4-hydroxy-3-methoxyphenyl)-3,5-heptanedione; HZIV 81-2; NSC 687845; Sabiwhite; Tetrahydrodiferuloylmethane |
CAS Number | 36062-04-1 |
Molecular Formula | C??H??O? |
Appearance | Light Yellow to Yellow Solid |
Melting Point | 89-93°C |
Molecular Weight | 372.41 |
Storage | Amber Vial, -20?C Freezer |
Solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
Stability | Light Sensitive |
Category | Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; |
Applications | Tetrahydro Curcumin is a major metabolite of Curcumin (C838500) that has been shown to have protective effects against diabetes and vascular dysfunction via alleviation of oxidative stress. |