Xi'an Quanao Biotech Co., Ltd.
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China (Mainland)
Business Type:Manufacturers
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Tel: +86 15529365669
Tel: +86-29-86719484
Tel: +8615529365669
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Tel: +86-29-86719484
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Province/state: Shaanxi
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Ms.Nora Yu Ms.YukiCAS NO.22888-70-6
80%(1-10)Kilogram80%(10-25)Kilogram80%(25-100)Kilogram
Hot sale Silibinin Offer Milk Thistle Extract 80% Silibinin 22888-70-6 in China
Silybin is the major flavonolignan found in milk thistle (S. marianum). It inhibits wild mushroom tyrosinase (IC50 = 1.7 μM).Silybin scavenges superoxide radicals (IC50 = 55.2 μM) and inhibits lipid peroxidation in vitro (IC50 = 73.92 μM).
Silybin is an inhibitor of a wide variety of proteins, many of which are heavily involved in xenobiotic efflux and metabolism. Silybin is an inhibitor of P-glycoprotein-mediated cellular efflux and also inhibits xenobiotic oxidation by the CYP (cytochrome P450) superfamily of enzymes. This helps to contribute the apoptotic activity of this compound, which has been shown to be effective against a wide variety of cancer cell lines. Silybin is an inhibitor of 5-LO.
The major active component of silymarin flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum; it is used in the treatment of HEPATITIS; LIVER CIRRHOSIS; and CHEMICAL AND DRUG INDUCED LIVER INJURY, and has antineoplastic activity; silybins A and B are diastereomers.
Silibinin (Silybin)
C25H22O10
482.44
22888-70-6
Enterprise Standard
| Catalogue Number | S465855 |
| Chemical Name | Silybin A |
| Synonyms | (2R,3R)-2-[(2R,3R)-2,3-Dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one; 3,5,7-Trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxan-6-yl]-4-chromanone; [2R-[2α,3β,6(2R*,3R*)]]-2-[2,3-Dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one; Silybin; 1,4-Benzodioxin, 4H-1-benzopyran-4-one deriv.; 7C3MT; Mepasil; Silibinin; Silibinin A; Silliver; Silybin b1; Silybine; Silybum substance E6; Silymarin I; Silymarin MZ 80; Silymarine I |
| CAS Number | 22888-70-6 |
| Alternate CAS # | Silybin B: 142797-34-0 / Diastereomer Mixture: 802 |
| Molecular Formula | C??H??O?? |
| Appearance | Pale Yellow Solid |
| Melting Point | 173-176°C |
| Molecular Weight | 482.44 |
| Solubility | Acetone (Sparingly), DMSO, Methano (Sparingly) |
| Category | Standards; Pharmaceutical/API Drug Impurities/Metabolites; |
| Applications | Silybin A is the 2R, 3R, 7‘R, 8‘R isomer of Silybin (S465850); a natural occurring flavolignan that exerts anti-inflammatory and anti-fibrogenic effects on human hepatic stellate cells. |