Keywords

• Devil's Claw extract Harpagosides Buy
• 19210-12-9 Harpagosides powder
• 19210-12-9 High quality

Quick Details

• ProName: Devil's Claw extract Harpagosides Buy ...
• CasNo: 19210-12-9
• Molecular Formula: C24H30O11
• Appearance: Brown powder
• Application: Food Additive.
• DeliveryTime: 5-7 working days
• PackAge: Bottle, Drum, Vacuum Packed, Plastic b...
• Port: China major port
• ProductionCapacity: 55 Metric Ton/Month
• Purity: 99%
• Storage: Sealed, Dry,Avoid direct sunlight
• Transportation: By Express,By Air,By Sea,By Land
• LimitNum: 1 Kilogram
• Plant of Origin: Devils claw
• Testing Method: HPLC
• Product Ecification: Raw Materials Powder
• Heavy Metal: ≤10ppm
• Voluntary Standards: China Standard,CP
• Product Name: Devil's Claw extract
• Active Ingredient: Harpagosides
• Purity: 100% Natural extract
• Specification: Raw Materials Powder，2.5%，5%，10%
• Extraction Type: Solvent Extraction
• Part used: Root
• Grade: Food Grade
• MOQ: 1KG
• Free Sample: 5-10g
• Shelf Life: 2 years
• Latin Name: harpagophytum procumbens
• Dissolve: Water

Superiority

Devil's Claw extract Harpagosides Buy 19210-12-9 Harpagosides powder High quality

Harpagoside is an anti-inflammatory small molecule natural product originally isolated from the Harpagophytum procumbens (DevilÂ’s Claw) root, but can be isolated from other plants such as Crophularia ningpoensis Hemsl (Figwort). Treatment of HepG2 cells with Harpagoside demonstrated suppression of NF-κB nuclear translocation and degradation of IκB-α, blocking NF-κB activation. Multiple anti-inflammatory cellular effects were correlated with this blockade, as Harpagoside was observed to inhibit the expression of inflammation-mediating enzymes cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), and to reduce lipopolysaccharide-induced mRNA levels. The suppression of NF-κB activation is indicated as the mechanism beneath the anti-inflammatory effects of Harpagoside

Harpagoside has anti-inflammatory effects, it blocks lipopolysaccharide (LPS)-induced bone loss in an inflammatory osteoporosis model, and it does not prevent ovariectomy-mediated bone erosion in a postmenopausal osteoporosis model, it may lead to a partial prevention of obesity-induced atherosclerosis by attenuating inflammatory responses. Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-κB activation. Harpagoside exerts neuroprotection effect and ameliorates learning and memory deficit appears to be associated, at least in part, with up-regulation of brain-derived neurotrophic factor (BDNF) content as well as activating its downstream signaling pathways, e.g., MAPK/PI3K pathways.

Details