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Xi'an Quanao Biotech Co., Ltd.

Country: China (Mainland)

Business Type:Trading Company

Ms.Lisa Xue

Tel: +86-29-86719484

Ms.Nora Yu

Tel: +86 15529365669

Ms.Ruby

Tel: +86-29-86719484

Ms.Yuki

Tel: +8615529365669

Mobile: +86 17782579994

Tel: +86-29-86719484

Fax: +86-29-86719484

URL: http://www.quanaobio.com

Province/state: Shaanxi

City: Xi'an

Street: B-1604,Juncheng Guoji, Taiyuan Road, Weiyang distirct

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Best price Nifuroxazide Nifuroxazide powder Reliable quality 965-52-6 in China

CAS NO.965-52-6

  • FOB Price: USD: 26.00-39.00 /Kilogram Get Latest Price
  • Min.Order: 1 Kilogram
  • Payment Terms: D/A,D/P,T/T,Other
  • Available Specifications:

    98%(25-300)Kilogram98%(301-500)Kilogram98%(501-900)Kilogram

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Product Details

Keywords

  • Best price Nifuroxazide
  • Nifuroxazide powder Reliable quality
  • 965-52-6 in China

Quick Details

  • ProName: Best price Nifuroxazide Nifuroxazide ...
  • CasNo: 965-52-6
  • Molecular Formula: C12H9N3O5
  • Appearance: white powder
  • Application: Health care grade,API,
  • DeliveryTime: 5-7 working days
  • PackAge: Bottle, Drum, Vacuum Packed, Plastic b...
  • Port: China major port
  • ProductionCapacity: 55 Metric Ton/Month
  • Purity: 99%
  • Storage: Sealed, dry and refrigerated
  • Transportation: By Express,Air,Sea
  • LimitNum: 1 Kilogram
  • Related Substances: Nifuroxazide
  • Residue on Ignition: <5
  • Heavy Metal: <10ppm
  • Valid Period: 2 Years
  • Active Ingredient: Nifuroxazide
  • Specification: 99%
  • Einecs No.: 213-522-0
  • Application: Health care grade,API
  • Sample: 5-10g
  • MOQ: 1KG
  • Place of Origin: Shaanxi, China
  • Brand Name: QUANAO

Superiority

Best price Nifuroxazide  Nifuroxazide powder  Reliable quality 965-52-6 in China

Nifuroxazide is a nitrofuran antibiotic. It is active against strains of the enteropathogenic bacteria C. jejuniSalmonellaY. enterocoliticaShigella, and E. coli. It inhibits quorum sensing and virulence factor production in P. aeruginosa. Nifuroxazide inhibits STAT3 activity in a reporter assay (IC50 = ~3 µM) and decreases viability of U266 and INA-6 myeloma cells, which have constitutive STAT3 phosphorylation, with EC50 values of approximately 4.5 µM for both. It also decreases viability, migration, and invasion of, and induces apoptosis in, MCF-7, 4T1, and MDA-MB-231 breast cancer cells. Nifuroxazide (50 mg/kg per day) reduces tumor growth and prevents pulmonary metastasis in a 4T1 murine mammary carcinoma model. It also reduces diarrhea, weight loss, and colon inflammation in a rat model of acetic acid-induced ulcerative colitis.

Nifuroxazide is a broad-spectrum antibacterial agent that has been used for the treatment of infectious diarrhea since 1960’s. In 2008, it was discovered that nifuroxazide is a potent inhibitor of the transcription factor STAT3. Since then, the potential of nifuroxazide as an anticancer agent has been investigated.

Nifuroxazide is a nitrofuran compound inhibitor of STAT transcription factor signaling. Nifuroxazide is described to block constitutive phosphorylation of STAT3 by reducing Jak kinase autophosphorylation, decreasing the viability of myeloma cells depending on constitutive STAT3 activity for survival while not affecting normal peripheral blood mononuclear cells. Nifuroxazide produces decreases in tyrosine phosphorylation of Jak2 and Tyk2, and showed no effects on EGF receptor tyrosine kinase or Src kinase, indicating a relative specificity of Nifuroxazide for Jak2 and Tyk2. Nifuroxazide shows no inhibition of Akt or MAPK phosphorylation.

Details

Item Specifications
Appearance Bright yellow crystalline powder
Solubility Practically insoluble in water, slightly soluble in alcohol and practically insoluble in methylene chloride
Loss on drying 0.5% Max
Heavy metals(Pb) 0.002% Max
Sulphated ash 0.1% Max
Identification by IR The IR Spectrum confirms with the reference spectrum
Related substance Impurity A ≤0.005%Impurity B ≤0.3%Impurity C ≤0.3%Impurity D ≤0.3%Impurity E ≤0.3%Signal unspecified impurities ≤0.1%Total impurities other than E ≤0.5%Total ≤0.5%Disregard limit ≤0.05%
UV.Absorption The specific absorption at about 367nm is between 940-1000
Residual solvents Methanol  ≤0.3%Alcohol ≤0.5%
Acetic acid  ≤0.5%NM  ≤0.05%
Assay (On dried) 98.5~101.5%
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