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Xi'an Quanao Biotech Co., Ltd.

Country: China (Mainland)

Business Type:Trading Company

Ms.Lisa Xue

Tel: +86-29-86719484

Ms.Nora Yu

Tel: +86 15529365669

Ms.Ruby

Tel: +86-29-86719484

Ms.Yuki

Tel: +8615529365669

Mobile: +86 17782579994

Tel: +86-29-86719484

Fax: +86-29-86719484

URL: http://www.quanaobio.com

Province/state: Shaanxi

City: Xi'an

Street: B-1604,Juncheng Guoji, Taiyuan Road, Weiyang distirct

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Reliable quality 75330-75-5 in China Manufacturer Lovastatin powder

CAS NO.75330-75-5

  • msdsMSDS/COA Download

  • FOB Price: USD: 55.00-70.00 /Kilogram Get Latest Price
  • Min.Order: 1 Kilogram
  • Payment Terms: D/A,D/P,T/T,
  • Available Specifications:

    2%(1-5)Kilogram2%(5-10)Kilogram2%(10-25)Kilogram5%(1-5)Kilogram5%(5-10)Kilogram5%(10-25)Kilogram

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Product Details

Keywords

  • Reliable quality 75330-75-5
  • 75330-75-5 in China
  • Manufacturer Lovastatin powder

Quick Details

  • ProName: Reliable quality 75330-75-5 in China M...
  • CasNo: 75330-75-5
  • Molecular Formula: C24H36O5
  • Appearance: Red Fine Powder
  • Application: 1. Food additives, coloring agents (me...
  • DeliveryTime: 7-9
  • PackAge: 1kg with double plastic container insi...
  • Port: SHANGHAI
  • ProductionCapacity: 100000 Kilogram/Year
  • Purity: 5%
  • Storage: Stored in a clean, cool, dry area; kee...
  • Transportation: Express, sea, land, air
  • LimitNum: 1 Kilogram
  • Plant of Origin: Red Yeast Rice Extract
  • Testing Method: HPLC
  • Product Ecification: 5%
  • Heavy Metal: <10ppm
  • Voluntary Standards: Chinese standard
  • Product Name: Red Yeast Rice Extract Lovastatin
  • Appearance: Red Fine Powder
  • Extraction Type: Solvent Extraction
  • Grade: Food Grade/Cosmetic Grade, Cosmetics g...
  • Part: Red Yeast Rice Extract
  • Test Method: HPLC
  • Active Ingredient: 2% 5% Lovastatin
  • Shelf Life: 2 Years
  • Particle Size: 100% Pass 80 Mesh

Superiority

Reliable quality 75330-75-5 in China Manufacturer Lovastatin powder

Lovastatin is an HMG-CoA reductase inhibitor that was initially isolated from A. terreus. It is a prodrug of its more potent metabolite, lovastatin hydroxy acid (Item No. 10010339). Both competitively inhibit HMG-CoA reductase with Ki values of 1.4 and 0.6 nM for lovastatin and the open ring, hydroxy acid form, respectively. Lovastatin (8 mg/kg/day) reduces plasma cholesterol in dogs by 29% over a three week period. It also suppresses TNF-induced NF-κB activation (IC50 ~ 15 µM), which potentiates apoptosis in human myeloid leukemia cells and thus, may be useful in treating cancer. Formulations containing lovastatin were the first HMG-CoA reductase inhibitors to be used in the treatment of hypercholesterolemia.

There are two main sources of plasma cholesterol; one is exogenous cholesterol absorbed from dietary; the other is form endogenous biosynthesis in vivo, wherein the endogenous cholesterol accounts for 2/3 of the total cholesterol which makes it the primary target of lipid-lowering therapy.


Cholesterol biosynthetic pathway in vivo starts from acetyl coenzyme. HMG-CoA is first generated by the HMG-CoA synthase, and then reduced into mevalonate by HMG-CoA reductase; then went through phosphorylation to generates farnesyl pyrophosphate; further reduced to turtle-ene which finally converts to cholesterol through 20 steps including lanosterol and chain sterols, wherein the conversion of HMG-CoA to mevalonate via HMG-CoA reductase is the rate-limiting step in cholesterol synthesis, making HMG-CoA reductase is the rate-limiting enzyme. Therefore, the inhibition of HMG-CoA reductase activity can reduce the formation of endogenous cholesterol. A part of lovastatin structure, 3,5-dihydroxy heptanoic acid is quite similar with HMG-CoA and its inhibitory effect is 10,000 times higher than HMG-CoA intermediate so that it can competitively bind with HMG-CoA reductase to inhibit the synthesis of mevalonate lactone, and thus effectively reducing the speed of cholesterol synthesis in liver cells and ultimately inhibiting the biosynthesis of endogenous cholesterol.

Details

High Quality 100% Natural halal kosher certificate Red Yeast Rice Extract Powder 5% Lovastatin

Red kojic rice is milled as raw materials, adopt modern biological engineering technology to isolate the high quality red by liquid submerged fermentation of aspergillus refined but become, is a kind of pure natural, high safety, food additives are beneficial to human body health.Moreover, this product has bright color, pure color, full color and good photothermal stability. It is an ideal colorant for natural green food.

Product Name Red Yeast Rice Extract Lovastatin
Active ingredients Lovastatin: 5%
Specification 2% 5% 
Grade Medical / Food/Cosmetic Grade
Application Food coloring, raw materials for eye health products
Test Method HPLC
Shlfe life 24months

 

 

 

 

 

 

 

 

 

 

 

 

 

Product Function

1. Invigorate the spleen and eliminate food, invigorate the blood and remove blood stasis;
2. Lowering blood lipids, lowering total cholesterol, reducing enzyme inhibitors, directly inhibiting hng-coa reductase, and blocking cholesterol synthesis;
3. Lovastatin can effectively reduce the serum cholesterol content of patients with mixed familial and non-familial hypercholesterolemia.

Product Application

1. Food additives, coloring agents (meat products, juice, color wine, jam, beverage, candy, pastry, soy sauce, health vinegar, etc.;
2. Pharmaceutical coloring agents, functional health products;
3. Cosmetics category.

Company Profile

Product Packing And Transportation

FAQ

Q1: Can I get some samples
A: Yes, free samples(10-20g or enough to detection) are available for most of our products, you only need to pay the shipping cost.


Q2: How to confirm the quality before orders
A: Two ways, either by free samples, or send us the detailed specifications, we will arrange the production as per your requirement.

Q3: What's your MOQ
A: Normally 1 kg, but smaller quantity is also acceptable for some special products.

Q4: How about discount
A: Mainly based on quantity, also some promotional products with special discount from time to time.

Q5. What's the delivery lead time
A: 2-3 working days after payment.

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