Keywords

• fast delivery 73-03-0
• cordycepin for sale
• cordycepin powder 73-03-0

Quick Details

• ProName: fast delivery 73-03-0 cordycepin for s...
• CasNo: 73-03-0
• Molecular Formula: C10H13N5O3
• Appearance: Brown Yellow Powder
• Application: Used for health care product.
• DeliveryTime: Delivery time: 5-7 days after received...
• PackAge: 1kg with double plastic container insi...
• Port: Any inland port in China
• ProductionCapacity: 10 Metric Ton/Month
• Purity: 98%
• Storage: Cool Dry Place
• Transportation: Fedex,TNT,DHL,Air transportion,sea tra...
• LimitNum: 1 Kilogram
• Plant of Origin: Cordyceps Militaris
• Testing Method: HPLC
• Product Ecification: 1%
• Heavy Metal: ≤20ppm
• Voluntary Standards: ISO
• Active Ingredient: Cordycepin
• Molecular Formula: C10H13N5O3
• Molecular weight: 251.24
• Shelf Life: 2 Years Proper Storage

Superiority

fast delivery 73-03-0 cordycepin for sale cordycepin powder  73-03-0

Cordycepin is a nucleoside analog that acts as an anticancer and antifungal agent. Can be converted to 3'-deoxyadenosine triphosphate (3'-dATP), which inhibits ATP-dependent DNA synthesis. Inhibits growth of various tumor cells in vitro.

Most currently known Cordyceps fungus contains Cordycepin, which obviously plays an important role in the anti-tumor effect. Jagger believes the cordycepin contained in Cordyceps fungus can inhibit tumorigenesis through three possible mechanisms:
1. The free alcoholic group contained in cordycepin can be incorporated into the DNA of cancer cells and takes effect.
2. Cordycepin can inhibit the phosphorylation of nucleoside or nucleotide to generate the derivatives of diphosphate and triphosphate, thereby inhibiting the synthesis of nucleic acids in tumor cell.
3. Cordycepin can block the amination of xanthylic acid into guanylate.
In 1977, Müller et al found that cordycepin had strong inhibitory effect against the proliferation of L5718Y cell with the ED50 being 0.27μg; this inhibitory effect can be eliminated by adenosine but not 2'-deoxy-nucleosides; The tritium marked Cordyceps trial have showed that cordycepin can be incorporated into RNA rather than DNA. The cordycepin, inside the cell, can be phosphorylated to 3'-ATP; 3'-ATP has no effect on the activity of the DNA-dependent DNA polymerase α and β in L5718Y cells, but has strong inhibitory effect on the nuclear Poly (a) polysaccharide which will inevitably lead to a maturation defect of mRNA, further negatively affecting the formation of mRNA and protein synthesis. The anti-tumor effects of Cordyceps may be related to this mechanism. In 1997, the United States has applied cordycepin to third-period clinical trials for the treatment of pre-B and pre-T acute lymphocytic leukemia, while cordycepin also exhibit strong anti-fungal, anti-HIV viral and selective inhibition activity on the activity of Clostridium genus.

In 1985, with in vitro experiments, Jiang ping et al observed the cytotoxicity of Cordyceps sinensis and cultured mycelium (Qinghai) on ECA cells. For the treatment of in vitro cell culture ECA, the result showed that when they two were at the lowest effective concentration 0.405mg/ml and 25mg/ml, the total infection rate was 100%, 80%, respectively, indicating that the drug has different strengths of ECA cytotoxicity. Comprehensive in vivo tests speculated that the anti-tumor effect is correlated with the certain amount of 3'-deoxy-nucleosides contained in the drug and Cordyceps polysaccharides as well as the relative balance between the overall immune regulatory function of the drugs and its effect of maintaining body immunity. Cordyceps sinensis has certain cytotoxic effect, which is consistent with the report regarding to the strong cytotoxicity of cordycepin-resistant L1210.

Details