Keywords

• 6902-77-8 in stock
• lowest price Geniposide
• Supply Genipin

Quick Details

• ProName: 6902-77-8 in stock lowest price Genipo...
• CasNo: 6902-77-8
• Molecular Formula: C11H14O5
• Appearance: White Powder
• Application: Used for Anti-cancer, protect the live...
• DeliveryTime: Delivery time: 5-7 days after received...
• PackAge: 1kg with double plastic container insi...
• Port: Any inland port in China
• ProductionCapacity: 10 Metric Ton/Month
• Purity: 99%
• Storage: Cool Dry Place
• Transportation: Fedex,TNT,DHL,Air transportion,sea tra...
• LimitNum: 1 Kilogram
• Plant of Origin: Gardenia Jasminoides Ellis Extract
• Testing Method: TLC
• Product Ecification: 10:1
• Heavy Metal: ≤20ppm
• Voluntary Standards: ISO
• Active Ingredient: Genipin
• Molecular Formula: C11H14O5
• Molecular weight: 226.23
• Shelf Life: 2 Years Proper Storage

Superiority

6902-77-8 in stock lowest price Geniposide Supply Genipin

Genipin is a compound isolated from gardenia fruits. Genipin is a water-soluble bifunctional crosslinking reagent with low cytotoxicity. Genipin is used as a good cross-linker for proteins, collagen, gelatin, and chitosan cross-linking. In addition, genipin can be used as a regulating agent for drug delivery, as an anti-inflammatory agent, and as the raw material for gardenia blue pigment preparation.

Genipin, a compound isolated from Gardenis jasminoides Ellis fruits, is a cell-permeable inhibitor of UCP2 activity. Genipin also exhibits anti-inflammatory and anti-angiogenic properties by inducing apoptosis in FaO rat hepatoma cells and human hepatocarcinoma Hep3B cells.

Uncoupling protein 2 (UCP2) is a mitochondrial carrier protein that is expressed in pancreatic islets and has been shown to negatively regulate glucose-stimulated insulin secretion. High levels of UCP2 expression can disrupt pancreatic β cell function and downregulate insulin secretion thereby contributing to the development of type 2 diabetes. Genipin, a compound isolated from Gardenis jasminoides Ellis fruits, was originally identified as a protein cross-linking agent. Genipin is a cell-permeable inhibitor of UCP2 activity.Genipin, at 5 µM, increases glucose-stimulated insulin secretion in isolated pancreatic islets chronically exposed to high levels of glucose. Genipin also exhibits anti-inflammatory and anti-angiogenic properties by inducing apoptosis in FaO rat hepatoma cells and human hepatocarcinoma Hep3B cells.

Details

Genipin is a compound isolated from Gardenis jasminoides Ellis fruits which acts as a cell permeable inhibitor of uncoupling protein 2 (UCP2). Genipin increases glucose-stimulated insulin secretion, mitochondrial membrane potential and ATP levels in pancreatic island cells. Genipin has been shown to induce apoptosis and is a protein cross-linking agent. Genipin, at 5 μM, increases glucose-stimulated insulin secretion in isolated pancreatic islets chronically exposed to high levels of glucose. Genipin also exhibits anti-inflammatory and anti-angiogenic properties by inducing apoptosis in FaO rat hepatoma cells and human hepatocarcinoma Hep3B cells.