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Xi'an Quanao Biotech Co., Ltd.

Country: China (Mainland)

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Ms.Lisa Xue

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Bitter Sophora Root Extract 98% Matrine 519-02-8 low price 519-02-8 Matrine On Sale

CAS NO.519-02-8

  • FOB Price: USD: 310.00-317.00 /Kilogram Get Latest Price
  • Min.Order: 100 Kilogram
  • Payment Terms: D/A,D/P,T/T,Other
  • Available Specifications:

    98%(100-500)Kilogram98%(500-1000)Kilogram

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Keywords

  • Bitter Sophora Root Extract 98% Matrine 519-02-8
  • low price 519-02-8
  • Matrine On Sale

Quick Details

  • ProName: Bitter Sophora Root Extract 98% Matrin...
  • CasNo: 519-02-8
  • Molecular Formula: C15H24N2O
  • Appearance: White Powder
  • Application: 1. Used For Insecticide Bitter Sophora...
  • DeliveryTime: 7-9
  • PackAge: 1kg with double plastic container insi...
  • Port: Shanghai
  • ProductionCapacity: 100000000 Kilogram/Year
  • Purity: 98%
  • Storage: Stored in a clean, cool, dry area; kee...
  • Transportation: Express, air, sea.
  • LimitNum: 100 Kilogram
  • Plant of Origin: Sophora Root Extract 98% powder Matrin...
  • Testing Method: HPLC
  • Product Ecification: 98%
  • Heavy Metal: <10ppm
  • Voluntary Standards: Chinese standard
  • Product Name: Sophora Root Extract 98% powder Matrin...
  • Appearance: White Powder
  • Extraction Type: Solvent Extraction
  • Place of Origin: Shaanxi, China
  • Grade: Pharmaceutical and food grade
  • MOQ: 1kg
  • Package: 1kg/ Bag 25kg/drum
  • Certificate: ISO9001/Halal/Kosher
  • Specification: 100% Natural Sophora Root Extract
  • Shelf Life: 2 Years

Superiority

Bitter Sophora Root Extract 98% Matrine low price 519-02-8 Matrine  On Sale

Matrine is an alkaloid found in S. flavescens roots that has diverse biological activities. It inhibits LPS-induced splenocyte proliferation and release of IL-1 and IL-6 from mouse peritoneal macrophages in vitro. In mice, administration of matrine inhibits the development of LPS-induced hepatitis in a dose-dependent manner. Matrine reduces production of the hepatitis B surface antigen (HBsAG) and serum antigen (HBeAG) with IC50 values of 0.75 and 3.35 mg/mL, respectively, in vitro and inhibits viral replication in a duck model of hepatitis B. In vitro, matrine inhibits angiotension II-induced hyperplastic growth of cardiac fibroblasts in a dose-dependent manner.Matrine also inhibits proliferation of melanoma, breast, and colon cancer cells with IC50s ranging from 0.769-2.758 mg/ml.

Matrine is a biologically active alkaloid isolated from the root of the saphoro plant. It inhibits LPS-induced splenocyte proliferation and release of IL-1 and IL-6 from mouse peritoneal macrophages in vitro. Matrine has been studied for possible antiviral efficacy against hepatitis B and C, as well as impact against some skin diseases and forms of cancer.

Matrine (519-02-8) is a natural product found in the plant Sophora flavescens.  It has been found to possess myriad biological activities including a positive inotropic effect, reduced glucose intolerance and hepatic steatosis in a mouse model via activation of HSP72, various anti-cancer effects.  Matrine has also recently been shown to induce RIP3-dependent necroptosis in cholangiocarcinoma cells.

Details

Alternate Name Sophocarpidine; Matridin-15-one; (7aS,13aR,13bR,13cS)-dodecahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one
Peptide Sequence N/A
Appearance White to off-white solid
CAS # 519-02-8
Molecular Formula C??H??N?O
Molecular Weight 248.37
Purity ≥98%
Solubility ~10 mg/ml DMSO
SMILES O=C1CCC[C@@]2([H])N1C[C@@]3([H])[C@@]4([H])[C@]2([H])CCCN4CCC3
InChi InChI=1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-/m0/s1
InChi Key ZSBXGIUJOOQZMP-JLNYLFASSA-N
PubChem CID 125307543
MDL Number MFCD00210527
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.
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