Keywords

• 50-02-2 Dexamethasone powder
• good supplier 50-02-2
• Dexamethasone China

Quick Details

• ProName: 50-02-2 Dexamethasone powder good supp...
• CasNo: 50-02-2
• Molecular Formula: C22H29FO5
• Appearance: White powder
• Application: 1. Dextromethorphan powder is used to ...
• DeliveryTime: 7-9
• PackAge: 1kg with double plastic container insi...
• Port: Shanghai
• ProductionCapacity: 100000000 Kilogram/Year
• Purity: 99%
• Storage: Stored in a clean, cool, dry area; kee...
• Transportation: by express /air/sea
• LimitNum: 100 Kilogram
• Related Substances: Dexamethasone
• Residue on Ignition: ≤0.1
• Heavy Metal: ≤10ppm
• Valid Period: 2
• Item Name: Dexamethasone
• CAS NO.: 50-02-2
• Apparence: White Powder
• package: Aluminum Bag;Drums
• Purity: 99%
• Warranty: 2 Years If Keep It Well
• Certificate: GMP/ISO9001
• Payment: Trade Assurance;T/T;Western Union
• Tadalafil Source: China Factory
• Tadalafil Packing: 25kg/drum

Superiority

 Dexamethasone powder good supplier 50-02-2 Dexamethasone China

Dexamethasone is a synthetic glucocorticoid that binds the human glucocorticoid receptor with a higher affinity than a natural ligand, cortisol (K_d = 5 nM versus 17 nM, respectively).¹ Through receptor activation, dexamethasone has both transactivating and transrepressing effects on gene expression, producing, in general, anti-inflammatory results.

Dexamethasone is a synthetic glucocorticoid compound with potent anti-inflammatory activities. Dexamethasone binds more powerfully to the glucocorticoid receptor than cortisol dose. Usually, glucocorticoid receptors (GRs) bind to heat shock protein 90 (HSP90). For the receptors, dexamethasone binding promotes dissociation of the receptor from HSP90 and conversion of the receptor to the DNA (glucocorticoid responsive element, GRE)-binding state, resulting in inducing change in regulating mRNA expression that lead to anti-inflammatory reactions. 

Details

Dexamethasone is a glucocorticoid; anti-inflammatory. Reduces levels of activated NF-κB in immature dendritic cells (DCs) and inhibits differentiation into mature DCs. Induces differentiation of human mesenchymal stem cells (MSCs). Also used in the generation of liver organoids. Induces autophagy in acute lymphoblastic leukemia (ALL) cell lines. Acts as viral transduction enhancer by promoting intracellular shuttling of HIV-1 pre-integration complex to the nucleus. Additionally Dexamethasone pretreatment in vivo suppresses adaptive immune response to recombinant adenoviral gene transfer vectors.

Anti-inflammatory glucocorticoidDexamethasone is used to treat inflammatory and autoimmune conditions such as rheumatoid arthritis and bronchospasm. It is useful to study apoptosis, cell signaling pathways and gene expression. It is associated with marbofloxacin and clotrimazole and finds application in veterinary medicine to treat difficult ear infections in dogs. It is also used to treat horses with swelling of of distal limbs and general bruising in combination with trichlormethiazide. It is also an anti-inflammatory glucocorticoid.