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Ms.Nora Yu Ms.YukiCAS NO.472-61-7
1%(1-24)Kilogram1%(25-99)Kilogram1%(100-999)Kilogram1%(1000-10000)Kilogram
on hot selling Astaxanthin powder low price fast delivery 472-61-7
Guanfacine, a selective agonist of α2A receptor, is a sympatholytic drug to treat attention deficit hyperactivity disorder (ADHD) and hypertension. It lowers both systolic and diastolic blood pressure.
Guanfacine is an alpha2-adrenergic receptor (alpha2-AR) agonist with Ki values of 93, 1,380, and 3,890 nM for alpha2A-, alpha2B-, and alpha2C-ARs, respectively, in a radioligand binding assay. It has EC50 values of 52, 288, and 602 nM for alpha2A-, alpha2B-, and alpha2C-ARs, respectively, for stimulated [35S]GTPgammaS binding. It also binds to imidazoline receptor 1 (Ki = 19 nM in a radioligand binding assay).
Guanfacine (0.3-5 mg/kg) binds to adrenergic receptors in the central nervous system and lowers blood pressure in hypertensive rats in a dose-dependent manner. It also improves spatial working memory deficits induced by hypobaric hypoxia in rats. Formulations containing guanfacine are used in the treatment of high blood pressure and attention deficit hyperactivity disorder (ADHD). Formal Name: N-(aminoiminomethyl)-2,6-dichloro-benzeneacetamide, monohydrochloride. CAS Number: 29110-48-3. Molecular Formula: C9H9Cl2N3O . HCl. Formula Weight: 282.6. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 25 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: ClC1=C(CC(NC(N)=N)=O)C(Cl)=CC=C1.Cl. InChi Code: InChI=1S/C9H9Cl2N3O.ClH/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13,/h1-3H,4H2,(H4,12,13,14,15),1H. InChi Key: DGFYECXYGUIODH-UHFFFAOYSA-N.
| Cas No. | 29110-48-3 | SDF | Download SDF |
| PubChem ID | 71401 | Appearance | Powder |
| Formula | C9H10Cl3N3O | M.Wt | 282.55 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : ≥ 30 mg/mL (106.18 mM) *"≥" means soluble, but saturation unknown. |
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| Chemical Name | N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide;hydrochloride | ||
| SMILES | C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl.Cl | ||
| Standard InChIKey | DGFYECXYGUIODH-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C9H9Cl2N3O.ClH/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13;/h1-3H,4H2,(H4,12,13,14,15);1H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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