Keywords

• 141433-60-5 in China
• High purity Berberine HCL
• Berberine HCL powder 141433-60-5

Quick Details

• ProName: 141433-60-5 in China High purity Berbe...
• CasNo: 141433-60-5
• Molecular Formula: C20H18ClNO4
• Appearance: Yellow Powder
• Application: 1. This product has recently found tha...
• DeliveryTime: 7-9
• PackAge: 1kg with double plastic container insi...
• Port: Shanghai
• ProductionCapacity: 100000000 Kilogram/Year
• Purity: 99%
• Storage: Stored in a clean, cool, dry area; kee...
• Transportation: Express, air, sea.
• LimitNum: 25 Kilogram
• Plant of Origin: Coptis Chinensis Root Extract
• Testing Method: HPLC
• Product Ecification: 10%
• Heavy Metal: ＜10ppm
• Voluntary Standards: Chinese standard
• Product Name: Berberine HCL
• Appearance: Yellow Powder
• Extraction Type: Solvent Extraction
• Place of Origin: Shaanxi， China
• Grade: Pharmaceutical and food grade
• MOQ: 1kg
• Package: 1kg/ Bag 25kg/drum
• Certificate: ISO9001/Halal/Kosher
• Specification: 100% Natural Fish skin
• Shelf Life: 2 Years

Superiority

141433-60-5 in China High purity Berberine HCL Berberine HCL powder 141433-60-5

Berberine chloride, an isoquinoline alkaloid extracted from Goldenseal (Hydrastis canadensis L.) and many other plants, has been used in Traditional Chinese and Indian (Ayurvedic) medicines for its antimicrobial and antiprotozoal properties. Recent pharmacological studies on berberine have revealed its various pharmacological activities, such as anti-cancer, anti-inflammatory, anti-arrhythmic,anti-diabetic, cholesterol-lowering and neuroprotective effects, yet the exact mechanisms are unknown. However, it is reported that berberine is able to activate an enzyme called Adenosine Monophosphate-Activated Protein Kinase (AMPK).

Berberine (also known as berberine hydrochloride) is a natural isoquinoline alkaloid found in a wide variety of herbs, including goldenseal, barberry, goldthread, Oregon grape and tree turmeric.

Within these plants, the berberine alkaloid can be found in the stem, bark, roots and rhizomes (rootlike subterranean stems) of the plants. It has a deep yellow color - so much so that it has been used as a natural dye.

Berberine is found in a group of shrub plants called Berberis. It is also the main active component of two herbs that are popular in natural medicine: Coptidis Rhizoma and Phellodendri Chinensis Cortex.

In Traditional Chinese Medicine, these herbs have been used to naturally treat diabetes for centuries. This compound also has a long history of use for managing bacterial gastroenteritis, diarrhea and other digestive diseases. 

Alkaloids are defined as a class of organic compounds of plant origin containing mostly basic nitrogen atoms. Consuming them can have pronounced physiological actions on humans, especially pertaining to cardiovascular and metabolic health.
 

Details

The plant-based alkaloid berberine has potential therapeutic applications for breast cancer, although a better understanding of the genes and cellular pathways regulated by this compound is needed to define the mechanism of its action in cancer treatment. In this review, the molecular targets of berberine in various cancers, particularly breast cancer, are discussed. Berberine was shown to be effective in inhibiting cell proliferation and promoting apoptosis in various cancerous cells. Some signaling pathways affected by berberine, including the MAP (mitogen-activated protein) kinase and Wnt/β-catenin pathways, are critical for reducing cellular migration and sensitivity to various growth factors. Treatment with BBR(Berberine) in rats on the atherogenic diet reduced plasma total cholesterol and nonHDL cholesterol levels by 29%-33% and 31%-41%, respectively, with no significant differences being observed among the three doses. Berberine induced both apoptotic and autophagic death of HepG2 cells, which was associated with a significant activation of AMPK and an increased expression of the inactive form of acetyl-CoA carboxylase (ACC). Berberine did not show major effects on viability of HEK-293 embryonic kidney and HCT116 colon carcinoma cells and was not toxic in concentrations up to 20 μM. Berberine inhibited β-catenin transcriptional activity and attenuated anchorage-independent growth. As a result of berberine treatment, cellular levels of active β-catenin were reduced concomitant with an increase in the expression of E-cadherin.

 Function
1.Berberine hydrochloride has the function of removing heat and damp, relieving fire and eliminating toxins;

2.Berberine hydrochloride with the function of relaxing vascular smooth muscle and exciting other smooth muscle, such as bladder muscle, bronchial muscle and gastrointestinal muscel.

3.Berberine hydrochloride with the function of antimicrobial and antibacterial.Berberine hydrochloride primarily for the treatment of bacillary dysentery, pulmonary abscess, brucellosis, acute tonsillitis, maxillary sinusitis, oral and maxillofacial inflammation embolism.

Application
1.Berberine is a natural, herbal, botanical dietary supplement commonly available in pill, tablet, or capsule form.

2.Berberine is an alkaloid found in various plants, including goldenseal, barberry, Oregon grape, and goldthread.

3.Berberine exhibits a broad spectrum of antibiotic activity in test-tube, animal, and human studies.