Xi'an Quanao Biotech Co., Ltd.
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Ms.Nora Yu Ms.YukiCAS NO.1197-18-8
99%(25-50)Kilogram99%(51-99)Kilogram99%(100-300)Kilogram
1197-18-8 in China High purity Tranexamic acid Tranexamic acid powder 1197-18-8
Fibrinolysis, the cleavage of fibrin by plasmin, is a normal step in the dissolution of fibrin clots after wound repair. Tranexamic acid is an inhibitor of fibrinolysis that blocks the interaction of plasmin with fibrin (IC50 = 3.1 μM). It is a lysine mimetic that binds the lysine binding site in plasmin. Antifibrinolytic agents have value when fibrinolytic activity is abnormally high or when coagulation is impaired
It is an antifibrinolytic agent that is found to inhibit plasmin-induced fibrinolysis. Used in various hemorrhagic diseases , abnormal bleeding in operations. It is also used as a lysine analogue to characterize binding sites in plasminogen.
Tranexamic acid is an inhibitor of fibrinolysis that inhibits the interaction of plasmin with fibrin (IC50 = 3.1 µM in isolated human plasma).It decreases α-naphthylisothiocyanate (ANIT)-induced increases in the expression of the profibrogenic genes Timp1 and Col1a1, but not Itgb6, Tgfβ1, or Tgfβ2, and reduces protein levels of cytokeratin 19 (CK19) and type I collagen in the liver after 28 days in a mouse model of chronic bile duct injury
| Catalogue Number | T714505 |
| Chemical Name | Tranexamic Acid |
| Synonyms | trans-4-(Aminomethyl)cyclohexanecarboxylic Acid; AMCHA; Amchafibrin; Amikapron; Anvitoff; Bay 3517; CL 65336; Cyclocapron; Cyclokapron; Cyklokapron; DV 79; Exacyl; HAKU; Haematrix; TAMCHA; Tranexamic Acid; Tranol; Transamin; Transamin S; Transcam; Ugurol; Xamig; Xed; Zataranax; t-AMCHA; trans-Amcha; trans-p-(Aminomethyl)cyclohexanecarboxylic Acid; |
| CAS Number | 1197-18-8 |
| Molecular Formula | C?H??NO? |
| Appearance | White Solid |
| Melting Point | >260°C (dec.) |
| Molecular Weight | 157.21 |
| Storage | Hygroscopic, Refrigerator, Under Inert Atmosphere |
| Solubility | Methanol (Slightly), Water (Slightly) |
| Stability | Hygroscopic |
| Category | Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites; |
| Applications | Antifibrinolytic agent; blocks lysine binding sites of plasminogen. Hemostatic. |